Red palm oil protects against the consequences of oxidative stress when supplemented with dislipidaemic diets
Bester D.J., Van Rooyen J., Du Toit E.F., Esterhuyse A.J.
It is a well known fact that the modern diet contains either excess polyunsaturated fats or saturated fats, and rarely a balanced fat content. In recent research it was found that high concentrations of PUFAs in the diet may be detrimental to cardiovascular health by increasing oxidative stress. Previous studies showed that red palm oil (RPO) provided effective protection against ischaemia/ reperfusion injury. In this study we developed an oxidative risk induced diet (ORD), which is rich in PUFAs and low in SFAs, and a high saturated fat diet (HFD), which is rich in SFAs and low in PUFAs. These diets were either supplemented with RPO (experimental groups) or not supplemented (control). Our aim was to investigate whether RPO could offer protection against ischaemia/ reperfusion injury in these diets. Our results showed that RPO was able to protect against ischaemia/reperfusion injury in both an ORD and a HFD as indicated by an increased aortic output recovery.
These results suggest that the NO-cGMP pathway may be stimulated by RPO during oxidative stress. This in turn would lead to elevation of cGMP during reperfusion, which is associated with protection.Type your paragraph here.
Impact of dietary red palm oil (Elaeis guineensis) on liver architecture and antioxidant status in the blood and liver of male Wistar rats : peer reviewed original article
Ayeleso, A.O., Brooks, N.L., Oguntibeju, O.O.
Antioxidant status and liver histopathology in male rats fed with different doses of red palm oil (RPO) were investigated. Liver and plasma ferric reducing antioxidant power (FRAP), total glutathione (GSHt) in the red blood cells (RBC) as well as catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities in the RBC and liver were determined. Our results showed no significant differences (p>0.05) in both liver and plasma FRAP and RBC GSHt in the RPO fed groups when compared with the control group. CAT activities significantly increased (p<0.05) at both 2 ml and 4 ml RPO groups in both the liver and RBC. GPx activities in the RBC significantly (p<0.05) increased at 2 ml and 4 ml RPO when compared with the control group. RPO did not significantly increase SOD in the RBC while its activities were increased in the liver. There were no histopathological alterations in the liver of RPO fed groups when compared with the control rats. In conclusion, red palm oil could up-regulate the levels of antioxidant enzymes and hence, its dietary consumption could help to boost antioxidant status in the body and thus promote overall well-being.