Pharmacological potential of tocotrienols: a review
Haseeb Ahsan, Amjid Ahad, Jahangir Iqbal, Waseem A Siddiqui
In contrast to αT, despite no evidence that deficiency of other vitamin E forms would result in obvious clinical symptoms, accumulating evidence suggests that γT, δT, and tocotrienols seem to have unique properties that are superior to αT and relevant to prevention and therapy against chronic diseases even under conditions with adequate αT status. It is noteworthy that these bioactivities of tocopherols and tocotrienols including anti-inflammatory properties have been identified by mechanistic studies and subsequently substantiated in some preclinical models as well as clinical studies.
Hence, tocotrienols possess neuroprotective, antioxidant, anti-cancer and cholesterol lowering properties. Tocotrienols are thought to have more potent antioxidant and free radical scavenging properties due to their better distribution in the lipid layers of the cell membrane.