The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes
McE. JENKINSON, A. R. COLLINS, S. J. DUTHIE, K. W. J. WAHLE and G. G. DUTHIE
In conclusion, using a novel application of a sensitive molecular epidemiological technique to investigate the influence of nutrition on DNA stability, we have shown that dietary PUFA, within a nutritionally relevant range, may have potentially damaging effects and, by implication, may increase the risk of developing certain cancers if repair mechanisms are overwhelmed. Increasing intakes of lipid soluble antioxidants in the form of α-tocopherol protects against this oxidative DNA damage and suggests that increasing PUFA intakes should only be recommended when an adequate antioxidant intake is ensured.